Tuesday, March 11, 2008

Journal Science to take action on Kim Tae-Kook fraud?

ScienceNOW Daily News reported:

The investigation [of Tae Kook Kim] is not yet complete, but Lee Gyun Min, chair of KAIST's Department of Biological Sciences and head of the internal investigation committee, sent correspondence to Science stating that "our initial investigative results are strong enough to convince us that the two papers do not contain any scientific truth."

The Science paper appeared in 2005 and the second was published in Nature Chemical Biology in 2006. The Science paper described using nanoparticles to probe molecular behavior inside cells and ultimately to identify novel drug targets. "The reviewers were very enthusiastic about the paper," says Katrina Kelner, Science's deputy editor for biological sciences. The Nature Chemical Biology paper appeared a year later and reported that a cell's aging clock could be reset by modulating certain proteins identified by the technique described in Science.

Kim formed a company to commercialize technology related to the studies, according to Yeonsoo Seo, a member of the Department of Biological Sciences and part of the KAIST investigative committee. But on 12 February, the president of the CGK Co. Ltd. in Daejeon contacted KAIST officials, saying they could not reproduce some of Kim's results.


Seo says investigators immediately approached Kim, who couldn't provide notebooks or original data for the experiments. He left Korea a few days later.

Science posted an Editorial Expression of Concern about the paper on its Web site on Monday and expects the authors to be in touch shortly to retract the paper. It's not yet clear whether Kim will be among them.


"This was a big shock to me, a complete shock," says Robert Roeder, a biochemist at Rockefeller University in New York City, who supervised Kim's Ph.D. thesis from 1990 to 1994, after he graduated from Seoul National University.

IPBiz notes that the last quote brings to mind the line of Captain Louis Renault (Claude Rains) about "gambling in Casablanca." Roeder might try to recall that his student Kim Tae-Kook told a local newspaper: "I want to become another Hwang Woo-Suk for Korea." Looks like Kim obtained his objective, but Roeder's "shock" is no more convincing than Renault's shock over gambling in Casablanca.

See also

Just like Hwang Woo Suk? Another fraudulent paper in Science!


***In passing

Note European Patent EP1771736. This invention relates to a method for detecting interactions between molecules, such as, biomolecules, and relates to a method for screening target molecules, both in vivo and in vitro. In this invention, the first detecting material and the second detecting material are provided, wherein the first detecting material is bound to a localizer which is translocated by externally applied driving force, and the second detecting material is bound to a label. Thus, the complex of the first detecting material and the second detecting material can be detected reversibly by changing the strength of the externally applied driving force, and the target molecule can be screened effectively. [WO2006009398] CGK CO., LTD. (3rd Floor, E18-dong Korea Advanced Institute Science and Technology Guseong-dong, Yuseong-gu, Daejeon 305-701, KR)
Kim, Tae Kook 1109-1304 Yeolmae Maeul Apt (11-danji,Noeun-dong, Yuseong-gu, Daejeon 305-768, KR)

Note WO/2007/015632 [ATM AND ATR INHIBITOR]; CGK CO., LTD. [KR/KR]; Daejeon Bioventure Town, 461-58,, Jeonmin-dong, Yuseong-gu,, Daejeon, 305-811, (KR) (All Except US). KIM, Tae Kook [KR/KR]; 1109-1304 Yeolmae Maeul Apt., 11-danji, 552-3 Noeun-dong, Yuseong-gu, Daejeon 305-768 (KR) (US Only).

published patent application 20040121365, based on 10/624618


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