Sunday, March 02, 2008

Just like Hwang Woo Suk? Another fraudulent paper in Science!

After publishing his first paper in Science in July 2005, scientist Kim Tae-Kook told a local newspaper: "I want to become another Hwang Woo-Suk for Korea." Looks like Kim succeeded!

Two fraudulent papers are "A Magnetic Nanoprobe Technology for Detecting Molecular Interactions in Live Cells" published in Science in July 2005 and "Small Molecule-Based Reversible Reprogramming of Cellular Lifespan" released in Nature Chemicalbiology in July 2006.

AFP reported: The Korea Advanced Institute of Science and Technology (KAIST) said Friday, March 1, 2008 that it had suspended bioscience professor Kim Tae-kook for fabricating data in two papers, which had been hailed as breakthroughs and were published in two renowned journals (...) "Professor Kim manipulated microscopic photos to fabricate study results," Lee Gyun-Min, head of KAIST's Department of Biological Sciences, told reporters Friday at KAIST in the central city of Daejeon.

The Korea Times reported:

It is the second time in three years that Science has been entangled with faulty papers written by Korean scientists. The magazine had to retract two papers written by Hwang Woo-suk in January 2006 after his stem-cell cloning research was found to have faked data.

Kim's 2006 paper suggested ideas for increasing the human lifespan by ``reprogramming'' cells ― the research earned him much publicity. South Korea's President Roh Moo-hyun invited him to the Blue House and KAIST President Suh Nam-pyo praised him as one of the most likely Korean candidates to win the Nobel Prize.

It was one of Kim's students who first suspected the credibility of Kim's research, the school said.

``A postgraduate student, who was a co-author of the paper, notified the school that he tried to replicate some of the experiments in the paper several times but couldn't,'' said Lee Gyun-min, professor and the department chief of Biological Sciences. ``We summoned other authors and found that there were false data analyses in the two papers. We also have strong evidence that these were deliberately done under Kim's supervision.''

JoongAngDaily reported:

Kim Tae-Kook, a professor at the state-run Korea Advanced Institute of Science and Technology, published the results of his research in the world-renowned journal Science in 2005 and in Nature Chemical Biology in 2006.
But it turns out his research was faked.
Kaist announced the findings of an internal investigation on Feb. 29 that concluded Kim had exaggerated the results of his experiments by manipulating the magnification of microscopic pictures.
The shock is all the greater because these fresh allegations of scientific fraud follow hard on the heels of Dr. Hwang Woo-suk and his fabricated research findings.

See also

For a different false article in Science:

***** had written:

Magnetic nano probe used to see drug interactions inside living cells

Prof. Kim Tae-kook at the Korea Advanced Institute of Science and Technology and his associates developed a technology dubbed MAGIC, short for magnetism-based interactive capture. This state-of-the-art magnetic nano-probe technology uses fluorescent materials to check whether any drug can mix with targeted proteins inside the cell.
Read more in The Korea Times or in Nature Chemical Biology press release and abstract.

***See also

Small molecule–based reversible reprogramming of cellular lifespan, Nature Chemical Biology 2, 369-374 (2006)

Jaejoon Won1, Mina Kim1,2,5, Nuri Kim1,5, Jin Hee Ahn3, Woo Gil Lee3, Sung Soo Kim3, Ki-Young Chang1, Yong-Weon Yi1 and Tae Kook Kim1,4

Top of page
Most somatic cells encounter an inevitable destiny, senescence1, 2. Little progress has been made in identifying small molecules that extend the finite lifespan of normal human cells. Here we show that the intrinsic 'senescence clock' can be reset in a reversible manner by selective modulation of the ataxia telangiectasia–mutated (ATM) protein and ATM- and Rad3-related (ATR) protein with a small molecule, CGK733. This compound was identified by a high-throughput phenotypic screen with automated imaging. Employing a magnetic nanoprobe technology, magnetism-based interaction capture (MAGIC)3, we identified ATM as the molecular target of CGK733 from a genome-wide screen. CGK733 inhibits ATM and ATR kinase activities and blocks their checkpoint signaling pathways with great selectivity. Consistently, siRNA-mediated knockdown of ATM and ATR induced the proliferation of senescent cells, although with lesser efficiency than CGK733. These results might reflect the specific targeting of the kinase activities of ATM and ATR by CGK733 without affecting any other domains required for cell proliferation.

which bears a correction, Nature Chemical Biology 3, 126 (2007) :

Corrigendum: Small molecule–based reversible reprogramming of cellular lifespan

Jaejoon Won, Mina Kim, Nuri Kim, Jin Hee Ahn, Woo Gil Lee, Sung Soo Kim, Ki-Young Chang, Yong-Weon Yi and Tae Kook Kim

Nature Chemical Biology 2, 369–374 (2006); published online 11 June 2006; corrected after print 22 December 2006

In the version of this article initially published, no competing financial interests were declared. The authors now declare that they have competing interests that might be perceived to influence the results and discussion reported in this paper, which are detailed in a declaration of competing financial interests accompanying the article. The error has been corrected in the HTML and PDF versions of the article.

The Korean Society of Food Science and Nutrition

Cutting Edges in Biomedical Research

Tae-Kook Kim (KAIST, Korea)
Chemical genetics and chemical genomics: high throughput
profiling of drugs,
therapeutic genes and disease networks

which meeting also included:

Shin-Yong Moon (Seoul National University, Korea)
Therapeutic cloning

IPBiz notes that the mention of Moon returns us to the initial theme of being "just like Hwang." The careful reader of IPBiz will remember the name Shin-Yong Moon.

Picture of "son of Hwang" fraudster Tae - Kook Kim, who promised to extend human life.


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