Friday, April 29, 2016

Fluorosamine for myelin regeneration?

See Multiple sclerosis: Drug boosts myelin regeneration in mice raising hope of future treatments for MS

Note the paper -- Changes in chondroitin sulfate proteoglycans in experimental autoimmune encephalomyelitis -- in Journal of Neuroimmunology, Volume 275, Issues 1–2, 15 October 2014, Pages 175, with text

Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central nervous system involving a profound destruction of myelin and oligodendrocytes that form focal areas of demyelination. MS also involves global changes in the extracellular matrix, including alterations in chondroitin sulfate proteoglycans (CSPGs). CSPGs may play detrimental roles in MS through their ability to reduce oligodendrocyte precursor cell recruitment, as well as promote local immune responses. However, the effects of CSPGs on MS pathology remain to be determined, as well as the role of specific CSPG members. (...)

Experimental autoimmune encephalomyelitis (EAE) was induced in C57Bl/6 mice, and animals were also treated with the glucosamine derivative fluorosamine that reduces CSPG production from cells in culture.


Treatment of mice with fluorosamine alleviated EAE clinical severity correspondent with decreased versican transcripts in the spinal cord. In active lesions of EAE as well as MS characterized by inflammatory perivascular cuffs, versican was detected on cellular and non-cellular profiles in the perivascular space.

The word "fluorosamine" appears in US Patent 4,621,059 : In this case, when luminol is used as the luminescent substance, iron ion is used for accelerating the luminescence. When the DNPO or TCPO is used as the luminescent substance, porphyrin, fluorosamine or dansyl compound may be used.

**Separately, from blawgsearch on 29 April 2016


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