60 Minutes on October 26, 2014
Lee Silver of Genepeeks was interviewed. Silver is the sole inventor of US Patent 8,805,620.
The first claim is
1. A method of selecting a donor or reproductive partner for a potential parent from a pool of sperm donors, or from a pool of oocyte donors or from a pool of potential reproductive partners, the method implemented by a computer processor executing program instructions, the method comprising the steps of: (a) using the processor, generating a recipient haplopath H.sub.i.sup.recipient={h.sub.1, h.sub.2, . . . , h.sub.N} including a single allele h.sub.x.di-elect cons.(1,2) of a genotype at each of a plurality of loci (1, . . . , N) from a recipient genome profile of a potential parent; (b) using the processor, generating a donor haplopath H.sub.i.sup.donor={h.sub.1, h.sub.2, . . . , h.sub.N} including a single allele h.sub.x.di-elect cons.(1,2) of a genotype at each of the plurality of loci x=1, . . . , N from a donor genome profile of a member of a pool of sperm donors, oocyte donors or potential reproductive partners; (c) using the processor, combining said recipient haplopath H.sub.i.sup.recipient with said donor haplopath H.sub.i.sup.donor to generate a virtual progeny genome sampling ##EQU00005## including two alleles h.sub.x.sup.recipient and h.sub.x.sup.donor of a genotype at each of the plurality of loci x=1, . . . , N for a potential progeny; (d) using the processor, comparing genotypes of said virtual progeny genome sampling to one or more databases of genotype-phenotype associations to determine a likelihood of expression of one or more phenotypes for the potential progeny having said virtual progeny genome sampling; and (e) repeating steps (a)-(d) for a plurality of recipient and donor haplopaths from, respectively, the recipient and donor potential parents i=1, . . . ,p to generate a virtual progeny genome G.sup.VP including a plurality of the virtual progeny genome samplings G.sup.VP=G.sub.1.sup.VP, G.sub.2.sup.VP, . . . , G.sub.p.sup.VP); (f) generating probabilities or probability distributions for said potential progeny expressing said one or more phenotypes based on the likelihoods determined for the plurality of virtual progeny genome samplings in the virtual progeny genome G.sup.VP; and (g) repeating steps (a)-(f) for each member of said pool of sperm donors, oocyte donors or potential reproductive partners.
Mark Hughes of a Genesis Genomics was also interviewed. Hughes had a problem at NIH back in 1997.
The first claim is
1. A method of selecting a donor or reproductive partner for a potential parent from a pool of sperm donors, or from a pool of oocyte donors or from a pool of potential reproductive partners, the method implemented by a computer processor executing program instructions, the method comprising the steps of: (a) using the processor, generating a recipient haplopath H.sub.i.sup.recipient={h.sub.1, h.sub.2, . . . , h.sub.N} including a single allele h.sub.x.di-elect cons.(1,2) of a genotype at each of a plurality of loci (1, . . . , N) from a recipient genome profile of a potential parent; (b) using the processor, generating a donor haplopath H.sub.i.sup.donor={h.sub.1, h.sub.2, . . . , h.sub.N} including a single allele h.sub.x.di-elect cons.(1,2) of a genotype at each of the plurality of loci x=1, . . . , N from a donor genome profile of a member of a pool of sperm donors, oocyte donors or potential reproductive partners; (c) using the processor, combining said recipient haplopath H.sub.i.sup.recipient with said donor haplopath H.sub.i.sup.donor to generate a virtual progeny genome sampling ##EQU00005## including two alleles h.sub.x.sup.recipient and h.sub.x.sup.donor of a genotype at each of the plurality of loci x=1, . . . , N for a potential progeny; (d) using the processor, comparing genotypes of said virtual progeny genome sampling to one or more databases of genotype-phenotype associations to determine a likelihood of expression of one or more phenotypes for the potential progeny having said virtual progeny genome sampling; and (e) repeating steps (a)-(d) for a plurality of recipient and donor haplopaths from, respectively, the recipient and donor potential parents i=1, . . . ,p to generate a virtual progeny genome G.sup.VP including a plurality of the virtual progeny genome samplings G.sup.VP=G.sub.1.sup.VP, G.sub.2.sup.VP, . . . , G.sub.p.sup.VP); (f) generating probabilities or probability distributions for said potential progeny expressing said one or more phenotypes based on the likelihoods determined for the plurality of virtual progeny genome samplings in the virtual progeny genome G.sup.VP; and (g) repeating steps (a)-(f) for each member of said pool of sperm donors, oocyte donors or potential reproductive partners.
Mark Hughes of a Genesis Genomics was also interviewed. Hughes had a problem at NIH back in 1997.
posted by Lawrence B. Ebert at 11:58 PM
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