Saturday, April 26, 2008

Gold nanoparticles and Curley paper

Steven A Curley and co-workers have an article: Intracellular gold nanoparticles enhance non-invasive radiofrequency thermal destruction of human gastrointestinal cancer cells

Of the rf field: A variable power 0–2 KW 13.56 MHz RF field generator (Therm Med LLC, Erie, Pennsylvania, USA) was built to specifications for use in these experiments.

Of "gold nanoparticles" [GNPs], the paper states:

GNPs were prepared using previously described methods. In brief, 50 mL of aqueous solution containing 4.3 mg of solid sodium borohydride was added to 100 mL of 100 μmol/L aqueous solution of tetrachloroauric acid under vigorous stirring for at least 12 hours. Nanogold particles formed and were then filtered through a 0.22 μm filter. Transmission electron microscopy (TEM) was utilized to confirm uniform creation of 5 nm GNPs [25].

IPBiz notes that there seems to be an acceptance of ANY particle which passes 0.22 microns (ie, smaller than 0.22 X 10-6 meter).
Does the text "uniform creation" mean that the ONLY particles formed (and used) were 5 nm in diameter? It would seem so.

Merely as background.

Analytical Biochemistry
Volume 236, Issue 1, 5 April 1996, Pages 168-170: Preparation of Colloidal Gold Particles of Various Sizes Using Sodium Borohydride and Sodium Cyanoborohydride

1906 discussion of conductivity of colloidal gold


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